For the first time, withanoside VII, 27-hydroxywithanone,ĭihydrowithaferin A, and viscosalactone B were quantified and validatedĪlong with bioactive compounds withanoside IV, withanoside V, withaferinĪ, 12-deoxywithastramonolide, withanolide A, withanone, and withanolideī simultaneously in WS. All compounds showed good recoveries ofĨ4.77–100.11%. Precise (relative standard deviation, <5.0%) and accurate (relativeĮrror, 0.01–0.76). The limits of detection and quantification were in the range of 0.213–0.362Īnd 0.646–1.098 μg/mL, respectively. The calibration curves were linear ( r 2 > 0.99) for all 11 compounds within the tested concentration Was carried out as per ICHQ2R1 guidelines in a single methodology. With photodiode array detection (UHPLC–PDA) analysis to separateġ1 withanoside and withanolide compounds. Root was subjected to ultrahigh-performance liquid chromatography In this study, the WS extract (WSE) from the Significance in neurodegenerative diseases, stress, cancer, immunomodulatory,Īnd antiviral activity. As ashwagandha or Indian ginseng, is known for its pharmacological
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